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榛勮敋 

涓闄笂娴疯嵂鐗╂墍鍗氬＋姣曚笟锛岀幇浠讳腑鍥界瀛﹂櫌涓婃捣鑽墿鐮旂┒鎵鐮旂┒鍛樸佸崥澹爺绌剁敓瀵煎笀銆佽棰樼粍闀匡紱浠诲浗绉戝ぇ鏉窞楂樼瓑鐮旂┒闄㈣嵂鐗╃瀛︿笌鎶鏈闄㈡墽琛岄櫌闀匡紝鍏间换涓浗绉戝鎶鏈ぇ瀛︺佸崕涓滅悊宸ュぇ瀛︺佷腑鍥借嵂绉戝ぇ瀛︺佹矆闃宠嵂绉戝ぇ瀛︺佸崡鏄屽ぇ瀛﹀吋鑱岀爺绌剁敓瀵煎笀锛涘鏈湡鍒奀hin. Chem. Lett.闈掑勾缂栧浼氬寲瀛︾敓鐗╁鍒嗗浼氬壇涓讳换銆併婁腑鍥借嵂鐗╁寲瀛︺嬬紪濮旓紱鍥藉鑷劧绉戝鍩洪噾銆佸浗瀹“閲嶅ぇ鏂拌嵂鍒涘埗”椤圭洰銆佷笂娴峰競绉戝鍩洪噾璇勫涓撳锛涘叏鍥藉崼鐢熶骇涓氫紒绠′細杞寲鍖诲鍒嗕細甯稿姟鐞嗕簨銆佺編鍥藉寲瀛︿細浼氬憳銆佷腑鍥藉寲瀛︿細绯栧寲瀛︿笓涓氬鍛樹細濮斿憳銆佷笂娴疯嵂瀛︿細鑽墿鍖栧涓撲笟濮斿憳浼氬鍛樸

鐮旂┒鏂瑰悜锛绯栫被鑽墿鐮斿彂銆

鑱氱劍绯栫被鑽墿鐮斿彂锛屽湪绯栧寲瀛﹀拰绯栫敓鐗╁浜ゅ弶棰嗗煙锛屽彂灞曟柊鐨勭硸绫昏嵂鐗╄璁℃妧鏈紝鍦ㄧ硸鍩哄寲浼樺寲鐨勫崟鍏嬮殕鎶椾綋鑽墿寮鍙戙佸熀浜庣硸閾惧畾鐐圭殑鎶椾綋鑽墿鍋惰仈鐗╋紙ADC锛夎嵂鐗╃爺鍙戙佹姉鑰愯嵂鑿岀殑绯栬偨鎶楃敓绱犵爺鍙戙佺硸鑻风被灏忓垎瀛愭姉鑲跨槫鑽墿鍙婃穻宸寸ず韪墏鐮斿彂绛夐」鐩笂锛屽彇寰椾簡绉瀬鐨勬垚鏋滐紝鐩稿簲鐨勮嵂鐗╁欓夊垎瀛愬湪杩涜绯荤粺鐨勪复搴婂墠璇勪环銆傜爺绌舵垚鏋滃湪Nat. Chem. Biol.銆丯at. Protocols銆丄ngew. Chem. Int. Ed.銆丣. Am. Chem. Soc.銆丣. Med. Chem.绛夋湡鍒婂彂琛ㄨ鏂70澶氱瘒锛岃浠栦汉寮曠敤鏁>2700娆★紝H-鎸囨暟涓28锛涚敵璇蜂笓鍒12椤癸紝宸叉壒鍑7椤广

浠ｈ〃鎬ц鏂囷細

1. Shi, W.^#; Tang, F.^#; Ao, J.; Yu, Q.; Liu, J.; Tang, Y.; Jiang, B.; Ren, X.; Huang, H.; Yang, W.^*; Huang, W.* (2020) “Manipulating the click reactivity of dibenzoazacyclooctynes: from azide click component to caged acylation reagent by silver catalysis.”  Angew. Chem. Int. Ed. doi.org/10.1002/anie.202009408.
2. Tang, F.^#; Zhou, M.^#,*; Qin, K.; Shi, W.; Yashinov, A.; Yang, Y.; Yang, L.; Guan, D.; Zhao, L.; Tang, Y.; Chang, Y.; Zhao, L.; Yang, H.; Zhou, H.; Huang, R.; Huang, W.* (2020) “Selective N-glycan editing on living cell surfaces for glyco-decryption of functions.” Nat. Chem. Biol. doi.org/10.1038/s41589-020-0551-8.
3. Guan, D.; Chen, F.; Qiu, Y.; Jiang, B.; Gong, L.; Lan, L.^*; Huang, W.^* (2019) “Sulfonium, an underestimated moiety for structural modification, alters antibacterial profile of vancomycin against multidrug-resistant bacteria” Angew. Chem. Int. Ed. 58(20), 6678-6682. DOI: 10.1002/anie.201902210
4. Guan, D.; Chen, F.; Xiong, L.; Tang, F.; Faridoon; Qiu, Y.; Zhang, N.; Gong, L.; Li, J.; Lan, L.; Huang, W.^* (2018) “Extra sugar on vancomycin: new analogues for combating multidrug-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.” J. Med. Chem. 61(1), 286-304.
5. Tang, F.; Wang, L.X.; Huang, W.^* (2017) “Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates.” Nat. Protoc. 12(8), 1702-1721.